SEDIMENTATION FIELD-FLOW FRACTIONATION APPLICATIONS (SEDIMENTATION FFF)

Sedimentation FFF is the benchmark in high resolution separation of nanoparticles, such as emulsions, latexes and any colloids dispersed in liquids or even emulsions. Sedimentation FFF in general is ideal for applications in biomedical, biotechnology, polymer, material and environmental science.

Characterization of Emulsions

Sedimentation FFF is ideally suited for separation and characterization of emulsions and drug delivery vehicles. It provides high resolution separation under gentle, low shear conditions. As an analytical-scale, elution-based technique, the size information is provided along with the separation. Thus the size distribution is a direct measurement, free from any assumptions. In comparison with other particle sizing techniques and any chromatographic separation techniques, Sedimentation FFF can separate sub-micron sized emulsion droplets of any density. The figure shows that Sedimentation FFF can give an insight into kinetics of emulsions and how they alter with time under certain conditions.

Characterization of Soils

The characterization of soil colloids with Sedimentation FFF coupled to ICP-MS gives the particles size information and at the same time the complete elemental distribution in the different size fraction can be determined. As an example, the figure shows the relative mass distribution determined by UV detection and the distribution of Al and Fe. Shown results have been published by J. F. Ranville1, R. Beckett2, and D. J. Chittleborough3, 1. Dept. of Chemistry and Geochemistry, Colorado School of Mines, Golden, USA; 2. Water Studies Centre, Monash University, Clayton, Australia; 3. Dept. of Soil Science, University of Adelaide, Glen Osmond, Australia.

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Flow FFF  |  Asymmetrical Flow Field Flow Fractionation  |  Thermal FFF  |  Sedimentation FFF
FFFractionation  |  Field-Flow Fractionation  |  Flow Field-Flow Fractionation  |  Asymmetric Flow Field Flow Fractionation  |  Thermal Field Flow Fractionation
Sedimentation Field Flow Fractionation  |  Split Flow Thin Cell